Semi-synthesis and insecticidal activity of spinetoram J and its D-forosamine replacement analogues

• Kai Zhang,
• Jiarong Li,
• Honglin Liu,
• Haiyou Wang and
• Lamusi A

Beilstein J. Org. Chem. 2018, 14, 2321–2330, doi:10.3762/bjoc.14.207

• and costs were significantly reduced. In addition, a variety of D-forosamine replacement analogues of spinetoram J were synthesized based on the improved semi-synthesis, and their insecticidal activities were evaluated against third-instar larvae of Plutella xylostella. Although none of the analogues

• products with other groups, and the improved semi-synthesis will be helpful for further researches on spinetoram. Keywords: analogues; forosamine replacement; improved semi-synthesis; insecticide; natural products; spinetoram; Introduction Nowadays, insect pests are one of the primary hazards that affect

• were no reports about the chemical modification of spinetoram. Therefore, in this study, a series of D-forosamine replacement analogues of spinetoram J were synthesized based on the improved semi-synthesis (Scheme 3), and the insecticidal activities of analogues were evaluated against third-instar